한국수산과학회

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  • pISSN : 2234-8395
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  • eISSN : 2234-1757

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kfas, vol. 52, no. 1, pp.81-86, February, 2019
DOI. https://doi.org/10.5657/KFAS.2019.0081

Effect of a Sargassum serratifolium Extract on Neuroinflammation
Induced by Lipopolysaccharides in Mice
LPS로 유도한 마우스의 급성신경염증에 대한 톱니모자반(Sargassum
serratifolium) 추출물의 효과

최민우·김형락·이형곤1·김재일*
부경대학교 식품영양학과, 1산안토니오텍사스주립대학교 생물학과

The common hallmark of several neurodegenerative disorders, including Alzheimer’s disease (AD), is the presence
of chronic neuroinflammation, which contributes to the loss of neuronal structure and function. This study investigated
the effects of an ethanolic extract of Sargassum serratifolium (SSE) in a lipopolysaccharides (LPS)-induced
murine neuroinflammation model. Mice were administered SSE (100 mg/kg body weight) or vehicle for 5 days by
oral gavage, and then treated with LPS or saline by intraperitoneal injection. Thereafter, the brain tissues were collected,
and the expression of pro-inflammatory cytokines was analyzed by quantitative real-time RT-PCR. There
was a marked increase in the spleen weight index in the LPS-treated groups, which indicated the induction of acute
systemic inflammation. Based on significant increases in the levels of IL-1 and IL-6 expression, the induction of neuroinflammation
was also evident in the cortex and hippocampus of the LPS-treated groups. The overall expression of
IL-1 and IL-6 was decreased slightly by SSE administration, compared with the LPS group, and a marked change in
IL-1 was observed in the cortex of the SSE-treated (SSE/LPS) group. These results suggest that SSE has potential as
an anti-neuroinflammatory nutraceutical.

Keyword : Neurodegenerative disorders, Neuroinflammation, Brown seaweeds, Sargassum serratifolium, Lipopolysaccharides

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