한국수산과학회

ISSN NUMBER

  • pISSN
  • :
  • 0374-8111
  • |
  • eISSN
  • :
  • 2287-8815

Open Access Journal

UTIL MENU



검색

kfas, vol. 54, no. 4, pp.552-560, August, 2021
DOI. https://doi.org/10.5657/KFAS.2021.0552

Anti-inflammatory Effect on RAW 264.7 Cells and Antibacterial Effect on Cutibacterium acnes of Compounds Isolated from Sedum takesimense 섬기린초(Sedum takesimense)에서 분리된 화합물들의 RAW 264.7 Cell에 대한 항염증 효과와 여드름 원인균에 대한 항균 효과

정은탁1,2·박슬기3·조경진2·정금재2·윤태미1 ·최태호1 ·김영목2,3*
1 다인소재, 2부경대학교 식품공학과, 3부경대학교 식품연구소

This study investigated anti-inflammatory and antibacterial activities of Sedum takesimense ethanolic extract, and 3 isolated compounds. To confirm anti-inflammatory and anti-acne activities, a nitric oxide (NO) inhibition assay, pro-inflammatory factor (TNF-α, IL-1β, and IL-8) inhibition assays, and minimum inhibitory concentration (MIC) tests were performed. The 3 isolated compounds were identified as 4,6-di-O-galloylarbutin (OGA), 2,4,6-tri-O-galloyl-glucose (OGG), and 1,2,4,6-tetra-O-galloyl-β-glucose (TOGG). The ethanolic extract and isolated compounds (OGA, OGG, TOGG) effectively inhibited production of NO and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-8). Furthermore, OGG and TOGG exhibited MIC values toward Cutibacterium acnes of 12.5 μg/mL and 3.2 μg/ mL, respectively. These results suggest that S. takesimense extract exerts an anti-inflammatory effect on LPS-induced RAW264.7 cells, and an antibacterial efficacy against C. acnes.

Keyword : Antibacterial activity, Anti-inflammatory activity, Cutibacterium acnes, Sedum takesimense

Download :


Copyrightⓒ 2014 The Korean Society of Fisheries and Aquatic Science
All Rights Reserved.

Editorial Office Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 608-737, Korea TEL : 82.51.629.7363 | FAX : 82.51.626.1039 | E-mail : kosfas@kosfas.or.kr