한국수산과학회

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kfas, vol. 54, no. 5, pp.644-651, October, 2021
DOI. https://doi.org/10.5657/KFAS.2021.0644

Anti-Viral Hemorrhagic Septicemia Virus (VHSV) Activity of 3-Methyl
Catechol
바이러스성출혈성패혈증 바이러스 감염에 대한 3-Methyl Catechol의
항바이러스성 활성

조세영1†·민나래2,3†·김영오2·김두운1,2*
1전남대학교 식중독바이러스연구센터, 2전남대학교 식품공학과, 3한국식품안전관리인증원 인증심사팀

Viral hemorrhagic septicemia virus (VHSV) is a fish pathogen responsible for causing enormous economic loss to the
aquaculture industry not only in Korea but worldwide. Thus, it is necessary to identify natural compounds that can be
used to control the spread of VHSV. In this study, the anti-VHSV activities of five catechol derivatives, i.e., catechol,
pyrogallol, 3-methyl catechol, veratrole, and 3-methyl veratrole-extracted from green tea-were assessed. The antiviral
activities of these derivatives were found to be dependent on their structure, i.e., the hydroxyl or methoxyl group
and their substituent groups-on the benzene ring. Catechol, pyrogallol, and 3-methyl catechol exhibited relatively
high 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities than veratrole, and 3-methyl veratrole.
Moreover, 3-methyl catechol harboring a methyl substituent group increased the viability of the virus-infected cells
and resulted in a 2.86 log reduction in the gene copies of VHSV N (per mL) in real-time PCR analysis. In conclusion,
the catechol derivatives harboring hydroxyl groups in their benzene ring exhibited higher antioxidant activities
than those harboring the methoxyl groups. However, catechol derivatives with a methyl group at the 3′-position of
the benzene ring exhibited higher antiviral activity than those harboring a hydroxyl group. To our knowledge, this is
the first study to evaluate the relationship between the structure and the anti-VHSV activity of catechol derivatives.

Keyword : Viral hemorrhagic septicemia virus, 3-methyl catechol, Antioxidant, Antiviral activity, Structure-activity relationship (SAR)

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