plSSN : 0374-8111 | elSSN : 2287-8815
plSSN : 0374-8111 | elSSN : 2287-8815
plSSN : 0374-8111elSSN : 2287-8815
김지윤†·박다빈†·이연지·문수경1*·김용태*
국립군산대학교 식품생명공학과/수산과학연구소, 1경상국립대학교 식품영양학과/농업생명과학연구원
In this study, we investigated the antioxidant and anti-dementia activities of the Korean marine algae Gloiopeltis tenax. Solvent extracts were prepared using 70% ethanol, 80% methanol, and distilled water. The extraction yields from the different solvents ranged from 8.52% to 49.47%. The total polyphenol and flavonoid contents ranged from 9.13-15.80 mg/g and 0.42-3.33 mg/g, respectively. The ethanol extract showed the highest 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity, whereas the methanol extract exhibited the strongest reducing power and ferric reducing antioxidant power. Additionally, both the ethanol and methanol extracts exhibited higher acetylcholinesterase inhibitory activities (IC50=0.89-0.95 mg/mL) than that of the water extract. In contrast, the water extract exhibited the highest β-secretase inhibitory activity (IC50=17.03 μg/mL). These results indicate that G. tenax may be useful as an antioxidant and functional ingredient for food and pharmaceuticals, particularly for its anti-dementia properties.
Anti-dementia, Antioxidative activity, Gloiopeltis tenax, Marine algae, Physiological activity